Upregulation of ADAM19 in dendritic cells is associated with immune features and lower C-peptide levels in type 1 diabetes mellitus - PubMed

3 hours ago

ADAM19 expression is consistently upregulated in dendritic cells (DCs) of type 1 diabetes mellitus (T1DM) patients compared to healthy controls.
Elevated ADAM19 in DCs is associated with altered immune cell proportions and reduced fasting C-peptide levels, indicating a link to immune dysregulation and β-cell dysfunction.
ADAM19 demonstrates potential as a biomarker for T1DM, with high diagnostic accuracy (AUC up to 0.93 in validation cohorts).
The study integrates bulk and single-cell RNA-seq data from PBMCs and pancreatic tissues, showing ADAM19's specific enrichment in DCs within the T1DM immune microenvironment.

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