Mediation Analysis Between Brain Age, Disease-Modifying Factors, and Disability and Cognitive Performance in Multiple Sclerosis - PubMed
4 hours ago
- #Brain Age
- #Multiple Sclerosis
- #Mediation Analysis
- Brain-predicted age difference (brain-PAD) is linked to greater disability and cognitive impairment in people with multiple sclerosis (MS).
- Smoking, alcohol consumption, and higher BMI at age 18 are associated with increased brain-PAD, while higher physical activity is linked to lower brain-PAD.
- Brain-PAD mediates the effects of smoking and alcohol on disability measures (EDSS, 9HPT, T25FWT) and cognitive performance.
- Physical activity shows an indirect beneficial effect on EDSS scores and cognitive performance through brain-PAD.
- The study suggests lifestyle interventions targeting factors like smoking and physical activity may help mitigate neurodegeneration in MS.