Twf1 regulates adipocyte proliferation and differentiation through Yap nucleus accumulation - PubMed
3 hours ago
- #Twf1
- #adipocyte differentiation
- #Yap signaling
- Twf1 is upregulated in white and beige adipose tissue of obese mice and downregulated after weight loss.
- Twf1 knockdown in C3H10T1/2 preadipocytes enhances white adipocyte differentiation, proliferation, and promotes Yap nuclear accumulation while inhibiting HIPPO signaling.
- Twf1 overexpression reduces differentiation, lipid droplet formation, and proliferation in C3H10T1/2 cells.
- Twf1 regulates adipocyte proliferation and differentiation through Yap nucleus accumulation, indicating a key role in obesity development.