Regulatory T cells in cancer and inflammation - PubMed

3 hours ago

Regulatory T cells (Tregs) maintain immune tolerance and prevent autoimmunity, exhibiting dual roles in cancer and inflammatory diseases.
In cancer, Tregs suppress antitumor immune responses and promote tumor immune evasion.
In inflammatory diseases, functional Tregs mitigate excessive immune activation and aid tissue repair, while dysfunctional Tregs contribute to chronic inflammation.
Tregs show instability and plasticity, shifting between functional and dysfunctional states under specific conditions.
Targeting Tregs is an emerging immunotherapeutic strategy, with research focusing on signaling pathways and microenvironmental influences on Treg behavior.
Recent advances in Treg-targeted therapies aim to develop precise and effective treatments for cancer and inflammatory disorders.

Hasty Briefsbeta