De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection - PubMed
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- #Post-COVID-19 Syndrome
- #Insulin Resistance
- #Neutrophil Extracellular Traps
- Insulin resistance (IR) developed post-COVID-19 in 67% of patients without prior glucose metabolism disorders (GMDs).
- Neutrophils from IR patients showed increased basal NETosis but impaired response to viral RNA-mimicking TLR7/8 agonists.
- Plasma from IR patients enhanced NETosis, with insulin identified as a driver independent of glucose levels.
- Targeting post-viral GMDs may reduce pathological NETosis and related thrombo-inflammatory risks.