Hallmarks and correlates of effective adoptive cell immunotherapy for cancer - PubMed
3 hours ago
- #Cancer Immunotherapy
- #Neoantigen
- #Adoptive Cell Transfer
- Adoptive cell transfer (ACT) using neoantigen-specific T cells can achieve tumor regression in metastatic solid tumors like melanoma, breast, and gastrointestinal cancers.
- Two main ACT approaches involve tumor-infiltrating lymphocytes (TILs) or T cell receptor-engineered T cells (TCR-T cells), targeting tumor-specific neoantigens from somatic mutations.
- Immunogenomics, systems immunology, and genome editing are multidisciplinary tools enabling the design of effective cell therapies against solid cancers.
- The review covers historical efforts, current understanding, and emerging correlates of response to ACT, along with next-generation strategies integrating tumor immunology, genomics, and computational biology.