Integrative Multiomics Analysis Reveals Tumor-Associated Macrophage Heterogeneity and a Prognostic Signature in Gastric Cancer - PubMed
3 hours ago
- #gastric cancer
- #tumor-associated macrophages
- #multiomics analysis
- The study integrated scRNA-seq, bulk transcriptomics, and spatial transcriptomics to analyze TAM heterogeneity in gastric cancer.
- ScRNA-seq identified nine major cell types and distinct macrophage subpopulations with tumor-specific expansion patterns.
- A seven-gene prognostic signature (UPP1, VCAN, ELL2, ABCA1, TUBA1A, MX2, TSPO) was developed using machine learning and showed robust survival prediction.
- Spatial transcriptomics revealed unique metabolic profiles and cellular interaction networks mediated by UPP1-expressing TAMs.
- The findings provide a comprehensive TAM atlas and establish novel biomarkers with potential therapeutic implications for gastric cancer.