TMEM184A-mediated autophagy in MHC-I degradation promotes tumor immune evasion - PubMed
3 hours ago
- #MHC-I degradation
- #autophagy
- #immune evasion
- TMEM184A is identified as a new regulator of tumor immune evasion in MSS colorectal cancers.
- TMEM184A functions as an autophagy receptor, binding GABARAPL2 to degrade IFN-induced MHC-I molecules.
- Genetic deletion of TMEM184A increases CD8+ T cell infiltration and MHC-I expression in cancer cells.
- Targeting TMEM184A or autophagy with chloroquine enhances anti-PD-1 therapy efficacy in TMEM184A-high tumors.