Microglial CD31 suppresses Aβ clearance and promotes Alzheimer pathology in 5×FAD mice - PubMed
3 hours ago
- #Alzheimer's Disease
- #Microglia
- #CD31
- CD31 is expressed at high levels in microglia in Alzheimer's disease (AD) patients and mouse models.
- Knocking down CD31 specifically in microglia of 5xFAD mice lessens microglial hyperactivation and reduces amyloid-beta (Aβ) deposition and inflammation, improving cognitive function.
- Mechanistically, CD31 knockdown disrupts SHP2 and STAT3 recruitment, leading to enhanced STAT3 activation, which promotes Aβ clearance via increased expression of membrane metalloendopeptidase (MME).
- The study identifies the microglial CD31-SHP2-STAT3-MME axis as a key regulator in AD pathogenesis and suggests CD31 as a potential therapeutic target for AD drug development.