Helical reconstruction of amyloids in cryoSPARC - PubMed
2 hours ago
- #amyloids
- #helical-reconstruction
- #cryoSPARC
- Amyloid filament structures are linked to over 50 diseases, but some have beneficial roles.
- CryoSPARC is underutilized for amyloid helical reconstruction compared to RELION, needing guidelines.
- Guidelines for helical reconstruction of amyloids in cryoSPARC are presented using public datasets.
- Amyloid-specific parameter tuning in cryoSPARC is crucial to overcome current limitations.
- Unsupervised workflows in cryoSPARC could aid high-throughput studies and drug development.