Amyloid Plaques Ameliorate Memory Deficits and Hippocampal Neuron Loss in an Aβ4-42-Driven Alzheimer's Disease Mouse Model - PubMed
3 days ago
- #Alzheimer's disease
- #Amyloid plaques
- #Mouse model
- Amyloid plaques may sequester toxic Aβ oligomers in early Alzheimer's disease.
- N-terminally truncated Aβ4-42 peptides are abundant in AD and cause neuron loss and cognitive deficits.
- A study crossed Tg4-42hom mice with 5XFAD mice to examine plaque effects on Aβ4-42 toxicity.
- Amyloid plaques rescued recognition memory deficits but did not worsen spatial memory in Tg4-42hom mice.
- Plaques reduced loss of distal CA1 pyramidal neurons but did not affect proximal neuron loss.
- Findings support the role of soluble Aβ oligomers in AD and plaques' buffering capacity.