SERCA2 deficiency in tubular epithelial cells drives ferroptosis in acute kidney injury regulating endoplasmic reticulum mitochondrial calcium homeostasis via voltage dependent anion channel 1 oligome
3 hours ago
- #ferroptosis
- #SERCA2
- #AKI
- SERCA2 expression is reduced in proximal tubules of patients and animal models with acute kidney injury (AKI).
- SERCA2 deficiency disrupts endoplasmic reticulum calcium homeostasis, promoting VDAC1 oligomerization via impaired mitochondria-associated endoplasmic reticulum membranes.
- This leads to mitochondrial permeability transition pore opening, calcium overload, oxidative stress, and ferroptosis in tubular epithelial cells.
- SERCA2 activation or inhibition of VDAC1 oligomerization attenuates AKI injury, identifying this axis as a therapeutic target.