Endothelial cells notch monocytes toward an alveolar macrophage fate - PubMed
4 hours ago
- #alveolar macrophage
- #monocyte differentiation
- #endothelial cells
- Endothelial cells direct monocytes toward an alveolar macrophage fate.
- A transcriptional network involving RBPJ, STAT5, SMAD4, RXRα, and PPARγ integrates DLL4, GM-CSF, and TGFβ signals.
- Endothelial DLL4 acts as an early signal enabling monocytes to acquire tissue-resident macrophage identity.