Immune System of the Ischemic Brain: Old Paradigms Revisited - PubMed
an hour ago
- #immune system
- #neuroinflammation
- #ischemic stroke
- The central nervous system is not immunologically privileged but engages in dynamic brain-immune interactions.
- After injury or disease, microglia and perivascular macrophages survey the brain, and immune cells infiltrate, contributing to neurovascular dysfunction and neuroinflammation.
- Systemic immune responses can also promote brain repair and recovery depending on timing and phenotype.
- Recent research highlights that communication between the brain and peripheral organs significantly influences injury progression and healing.
- This review redefines the neurovascular-immune interface and explores immune cell infiltration and brain-peripheral circuits in stroke recovery.