Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair - PubMed
3 hours ago
- #CNS repair
- #Astrocyte-microglia interaction
- #CSF1 and IFN-β crosstalk
- Astrocytes upregulate CSF1 after spinal cord injury, which is necessary for microglial proliferation, wound closure, and motor recovery.
- Astrocyte-targeted deletion of CSF1 reduces astrocyte numbers, indicating positive feedback regulation between astrocytes and microglia.
- Microglia produce IFN-β, which supports astrocyte survival, and disruption of interferon signaling in astrocytes impairs border formation, wound healing coordination, and motor recovery.
- The study reveals a synergistic crosstalk mechanism between astrocytes and microglia via CSF1 and IFN-β that enhances acute injury response for neural repair.