Spatiotemporal distribution of SARS-CoV-2 vaccines and vaccine-related proteins in mice and humans - PubMed
3 hours ago
- #spike protein
- #sputtering distribution
- #mRNA vaccines
- The study examined the spatiotemporal distribution of BNT162b2 and mRNA-1273 vaccines in mice and deceased humans.
- Vaccine-related mRNA and spike protein were detected at the injection site in both mice and humans, with muscle-associated fibroblasts identified as a primary source of spike protein expression.
- No expression of vaccine-related spike protein was found in immune cells at the injection site in either species.
- In humans, vaccine-related mRNA or spike protein was not detected in extramuscular organs, while in mice, it was present in several organs for up to 7 days post-vaccination.
- These findings contribute to understanding mRNA vaccine kinetics and distribution, aiding in the refinement of future mRNA-based therapies.