Roles of neutrophil extracellular traps in cancer immunotherapy resistance and therapeutic targeting - PubMed
4 hours ago
- #Immunotherapy Resistance
- #NETs
- #Tumor Microenvironment
- Neutrophil extracellular traps (NETs) contribute to resistance in cancer immunotherapy by shaping an immunosuppressive tumor microenvironment.
- NET components like cell-free DNA, MPO-DNA complexes, and citrullinated histones serve as diagnostic and prognostic biomarkers for disease progression and immunotherapy outcomes.
- NETs form physical barriers that lead to T-cell exhaustion and are regulated by tumor signals and exosomes.
- The review explores NET heterogeneity and mechanisms of resistance through spatial exclusion and biological modulation.
- Emerging strategies to target NETs include inhibiting formation, degrading barriers, and blocking downstream interactions to overcome immunotherapy resistance.