Two Doses to ICU or When Lactate Equals Glucose: Life-Threatening Lactic Acidosis due to Metformin After Initiation of Semaglutide - PubMed
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- #lactic acidosis
- #diabetes management
- #semaglutide
- GLP-1 agonists like semaglutide are increasingly used for diabetes treatment.
- Side effects include nausea, vomiting, and poor oral intake, which can cause rapid dehydration.
- Elderly patients with comorbidities on complex regimens are at higher risk for dehydration and acute kidney injury.
- Dehydration can lead to life-threatening metformin-induced lactic acidosis (MALA).
- Close monitoring is advised when starting semaglutide, especially with other diabetes medications in elderly patients.