Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease - PubMed
3 hours ago
- #Alzheimer's disease
- #Extracellular Vesicles
- #Tau seeding
- Tau profiling of brain extracellular vesicles (BD-EVs) from Alzheimer's disease patients identifies PHF6 peptide as a core driver of pathological tau seeding.
- The study compares tau proteoforms in BD-EVs across tauopathies, revealing unique tau peptide enrichment in Alzheimer's disease, particularly in the microtubule binding region.
- PHF6-containing proteins within Alzheimer's disease EVs are shown to mediate tau seeding activity, suggesting a key role in tau propagation and a potential therapeutic target.