Liraglutide and Recurrent Stroke by Baseline Insulin Resistance: A Post Hoc Analysis of the LAMP Trial - PubMed
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- #stroke prevention
- #insulin resistance
- Post hoc analysis of LAMP trial investigated liraglutide's effects on recurrent stroke relative to insulin resistance (IR) in patients with minor ischemic stroke or high-risk TIA and type 2 diabetes.
- Significant interaction between liraglutide treatment and IR observed: in patients with HOMA-IR ≥2.5, liraglutide reduced stroke recurrence (ARR 12.3%, NNT=8) and composite vascular events (ARR 13.4%, NNT=8).
- No significant benefit with liraglutide found in patients with HOMA-IR <2.5, suggesting IR as a key factor influencing treatment efficacy for secondary stroke prevention.