GPR15-guided CD8+ T regulatory cells control intestinal inflammation - PubMed
3 hours ago
- #immunology
- #inflammatory bowel disease
- #regulatory T cells
- GPR15 is identified as a homing receptor for a subset of regulatory CD8+ T lymphocytes (CD8+ TIGR cells) that control intestinal inflammation.
- Deleterious GPR15 gene variants in humans are associated with defective CD8+ TIGR homing and severe early-onset inflammatory bowel disease (IBD).
- CD8+ TIGR cells reduce intestinal inflammation by killing activated macrophages using Fas ligand (FasL) and TWEAK.
- In mice, GPR15 deficiency impairs colonic homing of CD8+ TIGR cells, leading to increased macrophage accumulation and susceptibility to colitis.
- This research provides insights into organ-specific immune regulation and potential therapeutic targets for IBD.