ZNF831 suppresses triple-negative breast cancer progression through NLRP3-associated pyroptotic signaling and M1-like macrophage phenotypic remodeling - PubMed
2 hours ago
- #Macrophage remodeling
- #Triple-negative breast cancer
- #NLRP3 inflammasome
- ZNF831 suppresses triple-negative breast cancer (TNBC) progression by enhancing NLRP3-associated pyroptotic signaling and promoting macrophage remodeling towards a pro-inflammatory M1-like phenotype.
- Higher expression of ZNF831 is linked to favorable patient outcomes, enhanced pyroptosis pathways, and a shift in the tumor microenvironment towards an M1-skewed macrophage profile.
- Mechanistically, ZNF831 regulates NLRP3 expression through promoter association and mRNA stability, leading to increased release of inflammatory cytokines like IL-1β and IL-18.
- Inhibiting NLRP3 with MCC950 in in vivo mouse models (using orthotopic 4T1-luc tumors) reversed the anti-tumor effects induced by ZNF831 overexpression.