Nitrate-Sialin Promotes Dentin Regeneration via Mitochondrial Rewiring - PubMed
3 hours ago
- #Dentin Regeneration
- #Mitochondrial Metabolism
- #Dental Pulp Stem Cells
- Nitrate acts via Sialin to promote dentin regeneration by rewiring mitochondrial metabolism in dental pulp stem cells (DPSCs).
- Nitrate reduces senescence in DPSCs across multiple models and restores odontogenic capacity, which is dependent on Sialin.
- Metabolomic analysis shows nitrate activates TCA and pyruvate pathways, boosting ATP, NAD+ redox ratio, and mitochondrial function while reducing reactive oxygen species.
- Pharmacological inhibition of electron transport negates nitrate's effects, linking metabolic changes to antisenescence and pro-odontogenic outcomes.
- In a mouse pulp exposure model, local nitrate accelerates dentin bridge formation, an effect lost in Sialin conditional-knockout mice, confirming the pathway's role in vivo.