Porcine epidemic diarrhea virus suppresses DHX9-mediated antiviral transcription through its nucleocapsid protein - PubMed
4 hours ago
- #antiviral transcription
- #DHX9
- #PEDV
- PEDV causes enteric disease in piglets and leads to economic losses in the swine industry.
- DHX9 functions as a host restriction factor against PEDV, with overexpression restricting replication and depletion enhancing it.
- DHX9 forms a transcriptional complex with STAT1 and RNA polymerase II to promote ISG expression for antiviral defense.
- The PEDV N protein binds to DHX9's STAT1-interacting region, disrupting the DHX9-STAT1-RNA polymerase II complex and suppressing antiviral transcription.
- The N protein also promotes ubiquitination and proteasome-dependent degradation of DHX9 by enhancing its interaction with E3 ligase MDM2.
- These mechanisms reveal how PEDV suppresses antiviral responses through disruption and degradation of DHX9.