Treatment-induced neuropathy of diabetes: A comprehensive literature review - PubMed
3 hours ago
- #Diabetes Complications
- #Glycaemic Control
- #Neuropathic Pain
- Treatment-induced neuropathy of diabetes (TIND) is an iatrogenic complication caused by rapid improvement in glycaemic control, often in patients with chronic hyperglycaemia.
- Common precipitators include rapid reduction in HbA1c due to insulin initiation/intensification, oral antihyperglycaemic therapy, or lifestyle interventions.
- Symptoms (e.g., severe distal neuropathic pain, paraesthesia, autonomic dysfunction) typically appear within 1 week to 6 months, most within 4–8 weeks.
- Management is mainly symptomatic, involving gabapentinoids, SNRIs, tricyclic antidepressants, or opioids.
- Most patients experience gradual improvement or resolution over months to a year, but persistent neuropathy can occur in a minority.