IL-6/STAT3 signaling drives mitochondrial oxidative phosphorylation dysfunction and AP-1 activation in fibroblasts during sepsis-induced lung injury - PubMed
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- #fibroblasts
- #lung injury
- #sepsis
- Fibroblasts shift from resting to pro-inflammatory and pro-fibrotic states in sepsis-induced lung injury.
- IL-6/STAT3 signaling leads to impaired mitochondrial oxidative phosphorylation, increased ROS, and AP-1 activation in fibroblasts.
- Clinical glucocorticoids like dexamethasone and methylprednisolone reduce lung injury by inhibiting the IL-6/STAT3/OXPHOS/AP-1 pathway.