Cross-species insights from ART-D to uncover evolutionarily conserved oncogenic mechanisms - PubMed
2 days ago
- #Cancer Research
- #Cross-species Platform
- #Oncogenic Mechanisms
- ART-D (Atlas of Ras-driven Tumors in Drosophila) is a cross-species platform analyzing RasV12-driven tumorigenesis across ten genetically defined models.
- Three conserved stages of tumor development are identified: initiation, promotion, and progression, marked by changes in tumor burden and cachexia.
- Early tumorigenesis involves co-activation of JAK/STAT, NF-κB/Toll, and MAPK pathways; malignant progression is driven by Notch hyperactivation and Hippo pathway inactivation.
- Integrative multi-omics and machine learning uncover a conserved pathogenic network coordinating JNK, NF-κB/Toll, Notch, and Hippo signaling, validated across species.
- ART-D bridges Drosophila genetics and human cancer biology, providing a framework to decode conserved oncogenic principles and identify stage-specific vulnerabilities in RAS-driven cancers.