Differential Immune Cell Distribution Between Arterial and Venous Blood in Healthy Rats - PubMed
3 days ago
- #arterial-venous axis
- #single-cell RNA sequencing
- #immune cells
- Immune cell distribution differs between arterial and venous blood in rats.
- T cells are enriched in arterial blood, while B cells, NK cells, and monocytes are more abundant in venous blood.
- Naïve T cells are enriched in arterial blood, whereas CD8+ effector memory T cells are increased in venous blood.
- Venous blood has cytotoxic NK subsets, and arterial blood has resting NK subsets.
- Transcriptomic analysis shows reduced JAK-STAT signaling in venous PBMCs.
- Venous T cells have reduced TNF/NF-κB signaling and enriched ribosome pathways.
- Venous NK cells show enhanced cytotoxic, chemokine, and NF-κB-related programs.
- Monocytes in venous blood have attenuated TNF/NF-κB signaling with increased ribosome activity.
- Blood sampling site is a critical determinant of immune readouts and a source of variability in studies.