The roles of the acetyltransferase domains of the KAT6A and KAT6B in vivo - PubMed
3 hours ago
- #Developmental biology
- #Histone acetyltransferase
- #KAT6 proteins
- KAT6A and KAT6B are functionally redundant histone acetyltransferases critical for development.
- Loss of KAT6A causes embryonic defects including skeletal transformations, heart abnormalities, and failed hematopoietic stem cell formation.
- Loss of acetyltransferase activity in KAT6A/KAT6B does not fully replicate the phenotypes of complete protein loss.
- Acetyltransferase mutants show ventricular septal defects and reduced hematopoietic stem cell activity but lack skeletal transformations and aortic arch issues.
- The findings indicate KAT6 proteins have functions beyond histone acetylation.