Frontotemporal dementia associated CHCHD10V57E mutation aggravates tau pathology via disrupting the CHCHD10-Rab7A-TBC1D15 complex - PubMed
4 hours ago
- #Tau pathology
- #CHCHD10 mutation
- #Frontotemporal dementia
- The CHCHD10V57E mutation is linked to Frontotemporal dementia (FTD) and worsens tau pathology.
- The mutation disrupts the CHCHD10-Rab7A-TBC1D15 complex, leading to Rab7A activation.
- In tauopathy models, CHCHD10V57E increases neurodegeneration, tau secretion, and cytotoxicity.
- Depletion of Rab7A partially mitigates these pathological effects.
- The study provides a mechanism by which CHCHD10 variants contribute to FTD-tau progression.