A BBB-permeable β3-AR probe enables redox imaging, natural inhibitors discovery, and therapeutic monitoring in glioblastoma - PubMed
3 days ago
- #glioblastoma research
- #β3-AR probe
- #redox imaging
- A BBB-permeable probe named GSHP was developed to visualize β3-adrenergic receptors and monitor redox status in real-time.
- GSHP enabled the identification of baicalin as a natural β3-AR inhibitor that induces oxidative stress-mediated apoptosis in glioblastoma cells.
- The probe facilitated in vivo dual-channel imaging of β3-AR overexpression and redox imbalance in mouse glioma models for therapeutic monitoring.