Proteomic Signatures of 3-Year Progression From Impaired Fasting Glucose to Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study - PubMed
3 hours ago
- #proteomics
- #impaired fasting glucose
- #diabetes progression
- Study aimed to identify proteomic signatures for 3-year progression from impaired fasting glucose (IFG) to diabetes.
- Used ARIC study data from 1990-1995 with 3,786 IFG participants; 3-year diabetes incidence was 6%.
- Analyzed 4,955 plasma proteins, identifying six significantly associated with progression: lower PTPRS, ANTXR2, ADIPOQ, CNTFR, TMEM132C, and higher ADAMTSL2.
- Key enriched pathways included altered carbohydrate metabolism and glycolysis.
- Adding these proteins improved prediction (AUC increase 0.03) and net reclassification (12.2% training, 12.0% validation).
- Two proteins validated in MESA cohort, supporting their role in diabetes risk stratification.