A DPHV-liver module recapitulates AML infiltration and chemotherapy-induced hepatotoxicity with translational utility - PubMed
2 hours ago
- #hepatotoxicity
- #drug screening
- #acute myeloid leukemia
- Developed a dynamic perfusable human vascularized liver module (DPHV-LM) using primary human hepatocytes in a perfusable scaffold.
- The DPHV-LM reproduced leukemic infiltration by perfusing AML patient-derived cells and modeled chemotherapy-induced hepatotoxicity.
- Identified ammonium glycyrrhizinate (AMGZ) as a compound that reduces cytarabine-induced liver damage and suppresses leukemic infiltration without affecting antileukemic efficacy.
- Findings from the DPHV-LM were qualitatively consistent with an independent retrospective clinical cohort, highlighting translational potential.
- Demonstrated utility for disease modeling, drug discovery, and developing hepatoprotective strategies in acute myeloid leukemia (AML).