NINJ1 hypomethylation enhances endothelial dysfunction in brain arteriovenous malformations - PubMed
3 hours ago
- #Epigenetics
- #Vascular Biology
- #Neuroscience
- NINJ1 hypomethylation is linked to endothelial dysfunction in brain arteriovenous malformations (bAVMs).
- Hypomethylation increases NINJ1 expression, enhancing endothelial cell proliferation, migration, and tube formation.
- NINJ1 activates KRAS-MAPK/ERK signaling by stabilizing KRAS protein.
- Overexpression of NINJ1 leads to increased endothelial permeability and reduced VE-cadherin and ZO-1 expression.
- In vivo studies in zebrafish show that endothelial-specific ninj1 overexpression impairs vascular integrity and causes intracranial hemorrhage.
- Epigenetic dysregulation of NINJ1 contributes to vascular instability and hemorrhage risk in bAVMs.