Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift - PubMed
2 hours ago
- #ATP regulation
- #polyphosphate
- #phosphate homeostasis
- Polyphosphate (polyP) synthesis is essential for recovery from phosphate starvation, not for entering starvation.
- The enzyme polyphosphate kinase (Ppk1) is required specifically during the transition from phosphate-limited to phosphate-replete conditions.
- PolyP synthesis prevents toxic accumulation of intracellular inorganic phosphate (Pi) when phosphate is reintroduced.
- Mutations reducing phosphate uptake via the Pst system can suppress the need for Ppk1, indicating polyP helps buffer Pi levels.
- Maintaining ATP homeostasis during nutrient shifts relies on polyP synthesis to regulate intracellular phosphate balance.
- This role in phosphate and ATP homeostasis facilitates adaptation to fluctuating nutrient conditions.