Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model - PubMed
2 hours ago
- #microglia
- #Gpnmb
- #neurodegeneration
- A microglial state with high Gpnmb expression emerges in prion-infected mice, linked to cell death regions.
- This Gpnmb+ state exhibits phagocytic and lysosomal gene signatures, but is not triggered by protein aggregates.
- Soluble factors from dying cells induce this microglial activation, revealing a general response mechanism to cell loss.