Pharmacokinetics of xylazine and fentanyl in patients presenting to the emergency department after non-fatal opioid overdose - PubMed
3 hours ago
- #Xylazine
- #Fentanyl
- #Pharmacokinetics
- A study examined pharmacokinetics of xylazine and fentanyl in 13 patients after non-fatal opioid overdose.
- Xylazine half-life (345±145 min) was longer than veterinary data predictions; fentanyl half-life (537±451 min) fell within literature upper range.
- Initial blood concentrations measured for xylazine, fentanyl, norfentanyl, and medetomidine, with medetomidine detected in five participants.
- The developed quantitative assay for xylazine and metabolites is suitable for clinical research.
- Understanding xylazine pharmacokinetics is vital for patient outcome projection and forensic analysis interpretation.