Prevalence of high-risk plasma p-tau217 levels and 5-year transition of risk status in 70-year-olds - PubMed
3 hours ago
- #Alzheimer's disease
- #longitudinal study
- #biomarkers
- High-risk plasma p-tau217 prevalence was 3.6% at age 70 and 7.0% at age 75-77 in a Swedish cohort.
- 89% of participants remained low-risk over 5-7 years, while 4% converted to high-risk.
- Dementia prevalence at follow-up was 1.7% in the low-risk group and 21.4% in those transitioning to high-risk.
- Participants staying in the high-risk group had a dementia prevalence of 16.7% at follow-up.
- Transitioning to a higher risk category was associated with higher cognitive disability prevalence.