CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin - PubMed
3 hours ago
- #Melanoma suppression
- #CSF1R-dependent
- #CD169+ macrophages
- CD169+ macrophages in the hypodermis are the main skin myeloid cells in steady state and localize around melanoma tumors in a mouse model.
- These macrophages directly suppress melanoma growth by encapsulating tumors and phagocytosing live cancer cells, independent of B, T cells, or MERTK receptor.
- Blocking CSF1R depletes CD169+ macrophages, leading to unchecked tumor growth, highlighting their role in innate immune containment of melanoma.
- CD169+ macrophages are enriched in human skin and melanoma biopsies, suggesting potential as a therapeutic target for enhancing tumor control.