ALS mutations do not alter perineuronal net formation in human stem cell-derived motor neurons - PubMed
3 hours ago
- #ALS
- #Motor Neurons
- #Perineuronal Nets
- Perineuronal nets are extracellular matrix structures that stabilize synaptic inputs and regulate neuronal plasticity.
- Human stem cell-derived motor neurons form PNN-like structures in co-cultures with astrocytes, which are not altered by ALS mutations.
- Meta-analyses show no consistent differences in PNN-related gene expression in stem cell-derived motor neurons with ALS mutations.
- Transcriptomic analyses of human post-mortem ALS tissues reveal dysregulation of PNN-related genes.
- PNN alterations in ALS animal models likely involve additional cellular components beyond motor neurons.