Metabolite-neuro-immune relay in chronic pain: spatial-temporal lactate, succinate and itaconate signalling as drivers of glial reprogramming and neuronal sensitisation - PubMed
3 days ago
- #chronic pain
- #metabolite signaling
- #neuroinflammation
- Chronic pain involves neuronal hyperexcitability and neuroinflammation, with metabolites like lactate, succinate, and itaconate signaling to drive glial reprogramming and neuronal sensitization.
- A metabolite-neuro-immune relay model describes how metabolic changes in astrocytes, microglia, and immune cells produce specific metabolite patterns, influencing glial states and resulting cytokines that remodel pain circuits.
- Spatial and temporal aspects of metabolic signaling create self-reinforcing neuroimmune loops, offering therapeutic targets such as modulating glycolysis, blocking succinate receptors, or enhancing the IRG1-itaconate-NRF2 axis for chronic pain treatment.