Herba Lysimachiae Polysaccharide-Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22-Regulated Mitophagy Activation - PubMed
an hour ago
- #kidney stones
- #nanoparticles
- #mitophagy
- Herba Lysimachiae polysaccharide-modified selenium nanoparticles (HLP-SeNPs) were developed to improve stability and antioxidant properties.
- HLP-SeNPs reduced oxidative stress, mitochondrial damage, and renal calcium oxalate crystal deposition in kidney stone models.
- Mechanism involves downregulation of TOMM22 to activate PINK1-Parkin mitophagy, targeting oxidative injury at its source.
- Findings support the potential of mitochondria-targeted nanotherapeutics by integrating traditional Chinese medicine with nanomaterials.