Comparative effectiveness of budesonide EC and telitacicept in proteinuria and eGFR trajectories in IgA nephropathy: a retrospective cohort study - PubMed
3 hours ago
- #IgA nephropathy
- #proteinuria reduction
- #renal function
- Budesonide EC and telitacicept were compared for treating IgA nephropathy in a retrospective cohort of 95 patients.
- Telitacicept showed greater proteinuria reduction benefit in patients with mild-to-moderate baseline proteinuria, with a significant interaction (P=0.003).
- Budesonide EC was associated with a higher mean eGFR in the primary analysis, but this attenuated after propensity score matching.
- The study highlights differential effects based on baseline proteinuria levels, but findings are limited by retrospective design and potential confounding.
- Further prospective studies are needed to confirm the comparative effectiveness of these treatments.