Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects - PubMed
2 hours ago
- #Undruggable Targets
- #Cancer Therapy
- #Nucleic Acid Therapeutics
- Nucleic acid therapeutics provide a new approach to target historically difficult-to-drug cancer proteins like Ras, MYC, and p53 by acting at the mRNA or genomic levels.
- Various nucleic acid modalities, including ASOs, siRNAs, miRNAs, aptamers, and mRNA vaccines, are discussed for their mechanisms, such as transcript degradation and translational inhibition.
- Key challenges for translation include delivery efficiency, safety profiling, and scalable manufacturing, with recent advances in nanocarrier platforms highlighted.
- Emerging technologies and computational design are explored as future directions to enhance the development and application of these therapies.
- This review underscores nucleic acid therapeutics as a paradigm shift enabling precise regulation of 'undruggable' cancer targets.