Clonal expansion of CAR-T cells harboring lentivector integration in the PLAAT4 gene following anti-CD19 CAR T-cell therapy in a context of cutaneous T-cell lymphoma - PubMed
4 hours ago
- #CAR-T cell therapy
- #Clonal expansion
- #T-cell lymphoma
- CAR-T cell clones with lentivector integration in the PLAAT4 gene expanded following anti-CD19 CAR T-cell therapy in cutaneous T-cell lymphoma.
- The study explores this phenomenon documented in a 2026 article (PMID: 42273948, DOI: 10.3324/haematol.2026.300851).
- While the abstract is noted as unavailable, it suggests research into unintended genetic effects and clonal dynamics post-CAR-T therapy.