FUS modulates R-loops by functionally interacting with RNase H1 - PubMed
3 hours ago
- #RNase H1
- #FUS protein
- #R-loops
- FUS regulates R-loop dynamics through interaction with RNase H1, helping to prevent their pathological accumulation.
- Depletion of FUS increases global R-loop levels and disrupts RNase H1's association with transcription machinery, highlighting its protective role.
- The FUS-RNase H1 axis is crucial for maintaining genomic stability, with implications for diseases like ALS and cancer where FUS is mutated.