Ketogenic Diet Modulates Depressive-Like Behavior via Gut Bacterial Metabolism of Tyrosine - PubMed
3 hours ago
- #Ketogenic Diet
- #Depression
- #Gut Microbiome
- The ketogenic diet (KD) shows potential for treating depression, but mechanisms are not well understood.
- KD rapidly alters the gut microbiome, and its depletion removes KD's protective effect against depressive-like behavior in mice.
- Colonization with Roseburia intestinalis, which increases after one week on KD, helps maintain KD's antidepressant effect.
- KD's protection is associated with reduced levels of p-Cresol sulfate (p-CS), a host-microbe co-metabolite.
- Supplementing p-CS negates KD's protective effect, as p-CS enters the brain and activates the lateral habenula (LHb), counteracting KD.
- Findings reveal a gut microbiota-brain axis mechanism through which KD protects against depressive-like behavior.