Targeted neuronal reprogramming rescues memory and neural synchrony in Alzheimer's disease - PubMed
3 hours ago
- #Yamanaka Factors
- #Neuronal Reprogramming
- #Alzheimer's Disease
- Targeted neuronal reprogramming using Yamanaka factors (YFs) in hippocampal neurons improves cognitive and emotional behaviors in a P301S tauopathy mouse model of Alzheimer's disease.
- Intermittent, neuron-specific YFs expression for six months enhances excitatory synaptic transmission, restores neural synchrony, reduces Tau pathology, and partially reverses epigenetic aging markers.
- Reprogramming rescues the composition and signaling of NMDAR macro-complexes, including key subunits and AD-associated risk factors like PYK2, suggesting this pathway mediates the therapeutic effects.