Mechanisms of intestinal adaptation in short bowel syndrome: what is the evidence? - PubMed
3 hours ago
- #intestinal adaptation
- #gut research
- #short bowel syndrome
- Short bowel syndrome (SBS) is defined by a remaining small bowel length under 200 cm after resection and carries a high risk of chronic intestinal failure.
- Intestinal adaptation in SBS involves structural changes like mucosal hyperplasia and functional adjustments such as altered transit and enhanced epithelial transporter expression.
- Most insights into adaptation mechanisms come from animal studies, with molecular pathways not fully understood due to variability in residual intestinal length.
- The review highlights that adaptation is time-dependent, with the most significant changes occurring early after resection and influenced by remaining GI tract anatomy.
- Longitudinal human studies are needed to complement animal models for identifying new therapeutic targets and improving patient outcomes.