Lactate-Associated Gene Signatures as Predictors: A Comprehensive Analysis of Immune Profiles in Sepsis - PubMed
2 hours ago
- #Immune Infiltration
- #Lactylation
- #Sepsis Biomarkers
- Sepsis is a complex disorder characterized by a dysregulated immune response to infection.
- Elevated lactic acid levels and lactylation modification may induce changes in gene expression and immune cell infiltration in sepsis.
- From RNA-seq data, 138 Sepsis-DELRGs (Sepsis-related differentially expressed lactylation-related genes) were identified.
- Mendelian randomization identified LYRM4 and MDC1 as protective factors against sepsis.
- LYRM4 and MDC1 positively influence CD8+ T cells and negatively affect activated mast cells and neutrophils.
- Both genes showed low expression levels in CD8+ T cells from sepsis patients.
- ROC curve analysis demonstrated that LYRM4 and MDC1 have strong predictive power for sepsis onset.
- LYRM4 and MDC1 could serve as potential biomarkers for differentiating sepsis patients from healthy individuals.